Abstract
This experiment showed that the characteristic difference in the regulation system of blood flow between normal and maligmant tissues was produced by angiotensin II induced hypertension (150 mmHg). Blood flow in tumor tissue of VX-2 carcinoma transplanted intramuscularly in rabbit was remarkably increased by angiotensin II induced hypertension, while blood flow in normal tissue of rabbit (liver, kidney, muscle), was almost constant after induction of hypertension. Based on this findings, a new approach to cancer chemotherapy, combined chemotherapeutic agent and angiotensin II, was discussed. Murine neuroblastoma (C-1300) transplanted intracutaneously in A/J mouse were employed in this experiment. Marked enhancement of the chemotherapeutic effect was noted in the group receiving active type cyclophosphamide (40487) intravenously under angiotensin II induced hypertension, compered with the control group and the group receiving active type cyclophosphamide (40487) alone intravenously. When angiotensin II and active type cyclophosphamide (40487) were given intraperitonealy, above enhancement of chemotherapeutic effect din not find out.
