Abstract
To invetigate the effects of the refluxed pancreatic juice on the biliary duct due to the age factor of canine models, pancreatico-choledochal anastomoses were performed experimentally on 24 canines, 12 in adult and 12 in puppy, as a model of anomalous arrangement of the pancreaticobiliary ductal system (AAPABIDS). The following results were obtained: 1) The dilatation of the choledochus was noted within one or two weeks after operation and the types of dilatation were spindle or cylindric in adult dogs and puppies. 2) The mean dilatation ratios of the choledochus were about 4.8-fold in adult dogs and 8.6-fold in puppies. 3) The mean elevation ratio of the amylase content level of adult dogs was higher than that of puppies. However, no significant difference of amylase level was found between adult dogs and puppies. 4) Common histological findings in these experimental models were desquamation of the lining epithelium, inflammatory cell infiltration and fibrosis of the wall. Mucous glands were seen in adult dogs and puppies. Goblet cells and argyrophil cell were seen in a puppy.
