Abstract
Familial occurrence of pheochromocytoma reported initially by Hyman in 1943 is rare and forty-seven cases of pheochromcytoma in nineteen pedigrees have previously reported in Japan. A nine-year-old girl with pheochromocytoma complained of headache, hypertension and visual disturbance. Her father who died at the age of 32, had been diagnosed as pheochromocytoma and other three persons in her family had been strongly suspected of this lesion with the history of severe hypertension and retinal hemorrhage. Analysis of previous Japanese literature indicated that the incidence of bilateral pheochromocytoma in case of familial occurrence was higher than in others and from the urinary catecholamine assay, the NA/AD ratio in familial pheochromocytoma was very high in comparison with Sipple's Syndrome.
