Abstract
We herein report three cases of an inflammatory myofibroblastic tumor. The first case was a 1-year-old boy with a high fever and anemia. A huge tumor was noted in the right hepatic lobe. The tumor was considered benign since the AFP level was not elevated. Surgical resection was performed to rule out hepatoblastoma. The second case was a 1-year-old boy with a history of repeated intussusception. A tumor was noted in the cecum and it was resected surgically. The third case was a 4-year-old girl with the symptom of bloody stool. A tumor was noted in the rectum and it was resected by the transanal approach. Local recurrence appeared and subsequently steroid therapy was given. The clinical efficacy was poor and surgery was again performed. The pathological diagnosis in all three cases was an inflammatory myofibroblastic tumor. The biology of this tumor covers a large spectrum of benign and malignant conditions. For this reason histological grading is paramount if effective treatment is to be given. Genetic analysis is expected to explain the pathogenesis of inflammatory myofibroblastic tumor and the role of genetic abnormalities as a prognostic factor.
