Idiopathic Posttransplantation Hepatitis in a Pediatric Liver Transplant Recipient: A Case Report

Abstract

De novo autoimmune hepatitis (AIH) can occur in patients who underwent living donor liver transplantation (LDLT). We encountered a male patient, who, at age 2 years, underwent LDLT owing to a failed Kasai operation. Seven years later, at age 10 years, serum, AST, ALT and globulin levels were markedly elevated, but he was negative for autoantibodies. Liver biopsy showed interface hepatitis. He was diagnosed as having idiopathic posttransplantation hepatitis and was treated with steroids. Although his liver enzyme and globulin levels rapidly returned to normal, a repeat liver biopsy continued to show interface hepatitis.