Clinicopathological Examination of Early Stage Bronchogenic Squamous Cell Carcinoma of Papillary Polypoidal Type

Abstract

Six resected cases of early stage papillary polypoidal squamous cell carcinoma were examined clinicopathologicaly, and compared with early stage non-papillary polypoidal squamous cell carcinoma. Cytomorphological findings obtained by optical and electron microscopy showed resemblance to those of the non-papillary polypoidal type. Some cases of non-papillary polypoidal tumor showed, though only partial, exophytic endobronchial papillary polypoidal growth, and intermediate type growth between both type. These findings seemed to indicate a close relation between both types of squamous cell carcinoma, and that not only the characteristics of the cancer cells, but also host immunoreaction to the tumor is one of the important factors in the formation of papillary pollypoidal squamous cell carcinoma. There was not much difference, between either type, in history, immunohistochemical findings and clinical findings such as smoking, age, location of the tumor, ring and nodular shadow on chest X-ray and respiratory function, except in the adjacent epithelium. Most of epithelium adjacent to papillary polypoidal tumors were almost normal, unlike those of non-papillary polypoidal tumor.