Studies on the influence of kallikrein on the coagulation mechanism, and change of prekallikrein by acu-puncture

Abstract

We observed the hypercoagulation in the blood of the patients after the acupuncture. The causes of the hypercoagulation were clarified by the works of kallikrein.
(1) Urine kallikrein increased the activity of Factor XII and fibrinolysis of the citrated plasma in vitro studies.
(2) Urine kallikrein (20 E. U.) increased coagulation, fibrinolysis and platelet function of the 2.5kg weighted rabbit. Antiplasmin and antithrombin III increased temporarily. Microthrombi were found in the lungs by autopsy.
(3) Factor XII was increased by acu-puncture which activate prekallikrein to kallikrein in the cases with thrombotic disease.