Abstract
In order to clarify the mechanism of DIC, the kinin-forming enzyme system which relates to bothcapillary permeability and blood coagulation was studied. Prekallikrein was determined by TAMe-or BAMe-lytic method.
The results obtained were as follows:
1. To obtain sufficient activation of prekallikrein to kallikrein, the concentration of factor XII was necessary to be more than 40%.
2. Since hemolysis caused the activation of prekallikrein, artifact hemolysis should be avoided.
3. BAMe was approximately 10 times more sensitive than TAMe.
4. Prekallikrein content was significantly lowered in the patients with obsterical acute DIC. This might be due to consumption. The activation of prekallikrein to kallikrein causes enhanced capillary permeability and lowered function of blood coagulation, and aggravates DIC with vitious cycle.
