Abstract
The effects of urokinase (UK) on blood coagulation and fibrinolytic activities in 19 cases with cerebral infarction and 2 cases with myocardial infarction were evaluated.
Each case was administrated with 60, 000 or 480, 000 international unit of UK per day and this therapy was performed for one or seven days.
The following results were obtained.
1) The hyperfibrinolytic effects such as shortened euglobulin clot lysis time, decrease of plasminogen and antiplasmin were observed, but significant increased level of FDP was not always obtained.
2) The remarkable changes of prothrombin time, partial thromboplastin time, fibrinogen, α1-antitrypsin and α2-macroglobulin were not observed at the end of UK infusion.
3) The decrease of antithrombin III was shown in the cases administrated with high dose of UK.
4) It was necessary for detecting of the effects of UK on coagulofibrinolytic system to do the serial assay of these factors after UK infusion.
5) Most of the cases with excellent or good clinical course exhibited the remarkable increased level of FDP in the early stage of UK therapy or lack of the findings of suggesting hypercoagulability. The bleeding complications induced by UK therapy was not observed.
These results show that it is important to administrate the dose of UK enough to induce the increased level of FDP in early stage and to prevent the hypercoagulability by anticoagulant therapy when UK therapy was performed in the cases with cerebral infarction and myocardial infarction.
