抄録
We have investigated plasma kallikrein system in various diseases. This study was undertaken to elucidate the mechanism changing the level of these factors in various disorders.
Factors of plasma kallikrein system were measured with TAMe hydrolysis method introduced by R. W. Colman. Factors in fibrinolytic system were measured with plasminogen free fibrin plate. Protease inhibitors (α1 antitrypsin, α1 antichymotrypsin C-1 inactivator, Inter α1 trypsin inhibitor, antithrombin III, α2 Macroglobulin) were measured by paltigen plates.
In 42 cases of hematological diseases, although the value of prekallikrein and enzyme inhibitor changed according to the patient's condition, only prekallikrein and plasminogen showed high correlation suggestive of the hypothesis that prekallikrein level changed due to the consumptive or degradation process. Enzyme inhibitor paralleled with α2 macroglobulin but not with C1 inactivator. This result was differ from in vitro investigation with purified materials.
In 89 cases of liver diseases, the value of prekallikrein showed parallel changes with that of enzyme inhibitor. They showed good correlation with antithrombin III, C1 inactivator. In 25 cases of liver cirrhosis, it was objous that prekallikrein and enzyme inhibitor correlated well with TP, A/G, Proth. T, HPT, antithrombin III, C1 inactivator.
This study clearly defined that in liver diseases, the prekallikrein and enzyme inhibitor changed the value according to the state of synthetic function of the liver, while in hematological diseases, the value changed according to the consumptive mechanism of the factors.
