Abstract
Previously, Lee & Walsh reported that the FDP was cleared by the RES. And we reported previously that the change of blood coagulation factor VIII are closely related to the activity of the RES.
Hepaplastintest (HPT), Thrombotest (TT), Prothrombin time (PT), blood coagulation factors I, V, VII, VIII, plasminogen, plasmin inhibitor plasminogen activator and FDP were measured in 5 patients with fulminant hepatitis and in mice with MHV-2 hepatitis.
The following results about FDP in blood were obtained.
1) In mice with MHV-2 hepatitis, the FDP in blood increased with the progression of hepatic necrosis. And furthermore, hepatic necrosis progressed, the FDP in blood decreased.
2) Increased FDP and increased factor VIII suggested primary fibrolysis.
3) Increased FDP and decreased factor VIII suggested secondary fibrinolysis.
4) Decreased FDP and increased factor VIII suggested hyperclearance of FDP by the RES.
5) Decreased FDP and normal factor VIII suggested slight hepatic necrosis.
6) Decreased FDP and factor VIII suggested final stage.
Therefore, FDP was determined by two important factors producing FDP by hepatic necrosis and clearing FDP by the RES.
