Abstract
A study was made on individual components of the fibrinolytic system and on the level of the degradation products of fibrinogen and fibrin (FDP) in children, mainly in pediatric patients. Plasminogen and whole inhibitor in the blood before and after the operation, were determined by an affinity chromatography and TNP method. FDP in the blood was determined by a latex agglutination test. The value of plasminogen was no difference between in healthy children and in adults and aged people, but the value of inhibitor was generally higher in healthy children than in adults and aged people.
Seventeen pediatric patients undergoing surgical procedures of various types were not induced significant change in plasminogen and inhibitor by surgical operation. From the viewpoint of a disease, the values of both plasminogen and inhibitor in patients with neuroblastoma were very low. An abnormal level of FDP was observed in patients with leukemia or hepatoblastoma.
