抄録
Fibrin-Fibrinogen degradation products (FDP) have been found in the serum and urine of many patients with renal disease.
To clarify the role of intraglomerular coagulation in renal disease, serum and urine FDP D-dimer was examined in reference to histology on 82 patients with several renal disease.
The results were as follows:
1. D-dimer in serum was found in 14 of 64 cases and that in urine in 14 of 34 cases.
2. Serum or urinary D-dimer positive cases had severer renal histological damages on light microscopy and more massive intraglomerular fibrin deposits by immunofluorescence in comparison with D-dimer negative cases.
3. The ratio of D-dimer to D fraction RD-D in urine FDP was higher than that in serum. This result suggests that there is acceleration of intrarenal coagulation and fibrinolysis in urinary D-dimer positive cases.
4. D-dimer in arterial blood, renal vein blood, and systemic vein blood of 14 cases were also examined, but any significant difference was revealed among the blood specimens.
5. There was a case which had more amount of fragment of γ-γ dimer in SDS-PAGE pattern of 2-mercaptoethanol reduced FDP in renal vein blood than that in arterial vein blood.
