It is well known that a high dietary intake of sodium chloride is one of the risk factors of hypertension and thrombotic cardiovascular diseases.
There are but few reports on the relationship between the dietary ingestion of sodium chrolide and platelet aggregability wich plays a very important role in the development of thrombotic disorders. Wistar rats and SHR, 5 weeks old, were divided into three groups and were treated for 10 weeks. Group A recieved a high sodium diet, Group B recieved a normo sodium diet and Group C recived a low sodium diet. At the end of 2, 5 and 10 weeks, blood was collected with 1/10 vol. of 3.8% Na citrate from abdominal aorta. PRP and PPP were obtained by centrifugation. Platelet aggregation was carried out with 5μM ADP. In Wistar rat, after 2 and 5 weeks on the study, platelet aggregability of the high sodium group was greater than that of the normo sodium group, which in turn was greater than that of the low sodium group. After 10 weeks on the study, platelet aggregability was same for all diet groups. In SHR the same tendency was observed.
In the present study, a close relation between the ingestion of high sodium diet and accerelated platelet aggregability was observed. Therefore, sodium rich diet may be one of the risk factor for the development of thrombotic disorders.
