抄録
GLM-3401 (GLM) is phyto-steryl-glucoside containing β-sitosteryl-β-D-glucoside, stigmasteryl-β-D-glucoside and campesteryl-β-D-glucoside, which is extracted from the plants. In animal experiment, it was shown that GLM has the effect of enhancement of vascular integrity and inhibition of increased permiability of capillary wall and the effect of hemostasis without significant influence on platelet function and blood coagulation system.
We investigated the effect of GLM on human platelets. One hundred twenty mg of GLM per day was administered orally for 7 days to 11 healthy persons (6 males and 5 females). The following laboratory tests were performed before and after administration of GLM, —platelet count, mean platelet volume (MPV), template bleeding time (TBT), platelet adhessiveness and aggregation, β-TG, PF-4, ATP release, prothrombin time, activated partial thromboplastin time, fibrinogen and antithrombin II.
GLM showed no significant effect on these tests except for TBT. The average value of TBT was 6.4±2.3min before administration of GLM and was 4.9±1.4min. after administration of GLM. This difference was statstically significant (p<0.05).
Since GLM showed shortening effect on TBT without significant effects on the other platelet function tests and coagulation tests, it is assumed that GLM has some influence on the interaction between platelets and vascular wall.
