Abstract
The contents of anti-Fragment D-dimer antibody-reacting antigen (Frag. D-dimer) in the serum of normal subjects and patiemts were determined by radioimmunoassay using specific antiserum against Frag. D-dimer. The content of Frag. D-dimer in normal subjects was 0.26±0.07μg/ml and that in patients with elevated levels of fibrinogen degradation products (FDP) distributed from 0.30 to 28μg/ml. They include patients with various malignant tumors, chronic renal diseases, sepsis, arterial diseases and liver cirrhosis with hepatoma. It was found that the amount of Frag. D-dimer and that of FDP did not necessarily change in paralell.
Plasma plasminogen and alpha-2 plasmin inhibitor were decreased in all disease groups except chronic renal disease. No remarkable decrease of alpha-2 macroglobulin was observed in any groups.
