Crude drugs of Wakan-Yakus (traditional herbal drugs) such as Gaiyoh (Artemisiae folium), Sanshishi (Gardeniae fructus), Taiso (Zizyphi fructus), Kizutsu (Aurantii fructus immaturus) and Akyoh (Glutinum) were investigated to analyse the effects on blood coagulation system.
(1) Gaiyoh (Artemisiae folium) showed the effects of anticoagulant, antifibrinolytic and anti-platelet aggregation, and the anticoagulant effect was strong prominently. When the crude drug of Gaiyoh was purified by the Sephadex G-100 column chromatography, four peaks were found. The strong antocoagulant effect was found to the third peak. We settled “Inhibition unit” of Gaiyoh from statistic studies, and 2.5mg/ml of Gaiyoh in the final concentration was evaluated to be 10 inhibition units.
(2) Sanshishi (Gardeniae fructus) showed strong fibrinolytic effect characteristically.
