Abstract
In order to make a molecular design for ideal antithrombogenic material, it is important to find an interaction between the material and platelets.
Homogeneous hydrophilic poly-2-hydroxyethylmethacrylate (PHEMA), hydrophobic poly-styrene (PSt) and HEMA-St ABA type block copolymer containing 0.608 mole fractions of HEMA which has hydrophilic and hydrophobic lamella microdomain and has lamellar structure of 300-500 Å in widths were prepared as experimental polymers.
Morphological changes of rat blood platelets adhered to the polymer surfaces in the microsphere columnar with Hanks' platelet solution (Ca++ Mg++free) were observed by transmission and scanning electron microscopes.
For the inhibition of platelet activation which was assessed by observing its deformities and degranulation, the surface of the material which has lamellarly-shaped microdomain was superior to the homogeneous one.
It was noted that the platelets have the ability to discriminate high dimension structure which forms the polymer surface, and the mode of platelet adhesion was found to be greatly influenced by the chemical structure of the polymer, its domain shape and the microstructural surface of the polymer.
