Abstract
Thrombus formation in carotid artery of adult wister rats (WR), young (8-9W) stroke-prone spontaneously hypertensive rats (SHRSP) or adult (18-19W) SHRSP was studied.
Electrode of anode was attached to the carotid artery and cathode was held the neighbor skeletal muscle. Three-mA direct current was discharged. Arterial occlusion was judged by the flow of evans blue dye which was injected through the femoral vein. Thrombus formation was quantified by a score of luminal setnosis of arterial transverse section. By 2min discharge, WR showed complete occlusion in all and 18±1.7 (mean±SE) in score at 15min after the discharge, in 50% (13±1.3) at 5min. By 1min discharge, occlusion in 25% (11±3.5) was observed at 15min.
Young SHRSP by 2min discharge showed occlusion in 85% (14±2.5) at 15min, but adult SHRSP did not have occlusion in all (5±1.5) at 15min. Pretreatment of tranylcypromine (i. v. or i. p.), PGI2 synthetase inhibitor, did not influenced in the thrombus formation of adult SHRSP.
From the results, arterial thrombus by an electric current depended on discharge time and period to the sacrifice from the disharge. Thrombus formation was markedly less in adult SHRSP than in WR, and was not restored by administration of PGI2 synthe tase inhibitor.
These results suggest that effects of synthetized PGI2 in arterial wall may be less effects than platelet aggregability and others to diminished arterial thrombus formation in adult SHRSP.
