トロンボキサン産生系を介さないヒト乳中の血小板凝集物質
1984 年 15 巻 3 号 p. 241-243
詳細
1984 年 15 巻 3 号 p. 241-243
The effect of a substanse in human milk on the several metabolic reaction in platelet and a few characterization of the substance were studied in this paper. The amount of thromboxane B2 produced after the aggregation did not differ from that of resting platelets. The activity of adenylate cyclase in platelet received the non competitive inhibition by the substance. Although the activity of cAMP phosphodiesterase was also inhibited by the substance, the inhibitory degree of the substance on the activity was less than that on the activity of adenylate cyclase. The platelet aggregating activity of the substance was lost by the heating at 100°C for 5min. and the treatment by trypsin and N-ethylmaleimide.
It was elucidated that platelet aggregating substance in human milk induce the aggregation by the mechanism unrelating to production of thromboxane B2 and is a high molecular protein, which need the SH group for occurence of the aggregating activity.
