Abstract
We have developed a radioimmunoassay technique to measure the fragment Eneo-antigens in plasma and applied this technique to healthy persons and patients. The Eneo-antigen level of 174 normal subjects was 2.2±1.9ng/ml. Analyzing on ages, the older persons were found to show higher Eneo-antigen levels. In 42 diabetes mellitus, Eneo level was 9.8±3.3ng/ml which was significantly higher than those of healthy. Hemodialyzed patients showed higher Eneo-antigen levels than healthy and, however, there was no significant change during the dialysis.