Abstract
Previously reported boosting effect of ultrasonic vibration on fibrinolytic activity of urokinase has been investigated experimentally in 40 Wistar rats.
Five and 24 hours after the injection of sodium laurate into a femoral artery to produce arteial occlusion, urokinase, 12.000iμ/kg each, given intravenously of followed directly by ultrasonic waves administration in bath in 12 rats, urokinase only was used 12 rats, ultrasonic vibration only were employed in 8 rats, and physiological saline solution was injected in 8 rats. The changes in the legs with laurate administration were observed for 12 days.
In rats with ultrasonic vibration only and also in those with saline solution, fingers developed gangrene after 24 hours of laurate injection, as were lost after 4 days. The leg was mummited after 12 days. In animals with urokinase and ultrasonic vibration, neither nocrotic changes, nor mummifications were seen. In rats with urokinase only, necroses in fingers were incomplete and mummifications were limited in fingers.
It was suggested that ultrasonic wave administration might reinforce fiibrinolytic effect of urokinase in vivo.
