Levels of VIIIR; AG and PA in the venous blood before and after 5 minutes tourniquet and fbg metabolism were determined in 19 patients with arterial thromboembolic disease and 4 age-matched healthy volunteers and the following results were obtained;
patient group control group p value
mean±SD mean±SD
VIIIR; AG before tourniquet (%) 206.1±60.7 117.5±14.4 p<0.025
VIIIR; AG after tourniquet (%) 243.7±58.3 145.0±12.9 p<0.01
PA before tourniquet (IU/ml) 0.084±0.049 0.139±0.032 p<0.05
PA after tourniquet (IU/ml) 0.136±0.073 0.545±0.497 p<0.005
fbg T/2 (day) 2.57±0.31 3.25±0.34 p<0.005
fbg J3x (mg/kg/day) 70.5±20.4 27.6±9.3 p<0.005
Correlations among these values were investigated, and significant relationship was obtained between VIIIR; AG after tourniquet and fbg J3x (r=0.425, p<0.05), PA after tourniquet and fbg T/2 (r=0.550, p<0.01), and increase in PA after tourniquet and fbg T/2 (r=0.463, p<0.05).
It is suggested from these results that the functionally changed endothelial cells of patients with thromboembolic disease participate in accelation of fbg metabolism.
