赤血球膜コレステロール含量に対する血漿高比重リポ蛋白コレステロール低下の影響
1985 年 16 巻 6 号 p. 609-613
詳細
1985 年 16 巻 6 号 p. 609-613
Recent studies have shown that high density lipoprotein (HDL) contributes to the pathogenesis of atherosclerosis and attention has been directed to HDL cholesterol (HDL-C) level as a negative risk factor against ischemic heart and cerebrovascular disease. The purpose of this study is to elucidate the influence of decreased plasma HDL-C on the content of red cell membrane cholesterol.
Red cell membrane cholesterol (RBC-C) was analysed in 24 survivors of cortical artery area infarction with decreased plasma HDL-C levels, whose plasma total and lipoprotein cholesterol were measured concurrently. The results were compared with findings in 9 controls with normal plasma HDL-C levels. Each cholesterol level in two groups was summarized in table 1. The mean value of RBC-C in patients was significantly increased, compared to that in the control group (Fig. 1). The content of RBC-C correlated negatively with that of plasma HDL-C (Fig. 2), and positively with the ratio of low density and very low density lipoprotein cholesterol (LDL+VLDL-C) to HDL-C (Fig. 3). Weak correlation was seen between the concentration of RBC-C and that of LDL+VLDL-C or total cholesterol (Fig. 4, 5).
The results suggest that the decreased content of plasma HDL-C will affect the pathogenesis of atherosclerotic disease by the increase of red cell membrane cholesterol.
