Calmodulin (CaM), an intracellular calcium binding protein, is widely distributed in human tissues and cells. A. sensitive radioimmunoassay for CaM has been applicated to tissue extracts and cells since it was developed recently. In the present study, the contents of platelet CaM in normal subjects and several diseases were determined using Calmodulin RIA Kit.
The results of this study were as follows: (1) The contents of CaM in platelet from patients with ITP, SLE, DVT. DIC, aplastic anemia, acute leukemia in recovery phase and MPD were significantly increased than that from normal subjects. (2) The contents of CaM in platelet from patients with ITP which responded to therapy tended to be decreased, comparing with those at initial diagnosis or those did not respond to therapy. (3) there was no correlation between the contents of CaM in platelet and platelet aggragability. (4) There was a negative correlation between the content of platelet CaM and platelet lifespan, indicating that the CaM level was inversely related to pletelet age.
