Plasma levels of β-thromboglobulin, prostaglandins and fibrinopeptides in patients with effort angina and their changes during the exercise-induced myocardial ischemia and effect of co-enzyme Q₁₀

Abstract

Platelet function, prostaglandins, coagulation and fibrinolytic states influenced by exercise stress were evaluated in 7 patients with effort angina. Upon exercise all patients exhibited positive tests for ischemia and platelet specific protein β-thromboglobulin (β-TG) increased significantly (p<0.01) suggesting intravascular platelet activation but thromboxane B₂ (TXB₂), 6-keto-PGF_1α, fibrinopeptide A (FpA) and fibrinopeptide Bβ 15-42 (FpBβ 15-42) stayed unchanged (Fig. 2). At rest, plasma β-TG, TXB₂, 6-keto-PGF_1α and FpA were in normal or near normal ranges but FpBβ 15-42 was increased suggesting an increased fibrinolytic state. Oral administration of oxygen radical scavenger co-enzyme Q₁₀ 120mg/day for 2-4 weeks prevented the exercise induced elevation of β-TG but exerted no effects on prostaglandins and fibrinopeptides.