Abstract
Spontaneously hypertensive rats (SHR) were discovered among Wistar Kyoto rats (WKY). In this study, prothrombin time, activated partial thromboplastin time, levels of factors II, V, VII, VIII, IX, X, XI, XII and XIII, plasma fibrinogen content, heparin cofactor activity (levels of antithrombin III) and activity of α2-plasmin inhibitor in plasma were determined using an automatic analyzer in 30 WKY (15 males and 15 females) and in 30 SHR (14 males and 16 females) with 10 weeks of age. Mean systolic pressure (±SD) measured using programmable sphygmomanometer in the tails of the rats elevated in SHR. Activities of factors VII and X and heparin cofactor activity in plasma were lower in SHR than in WKY. Levels of factors XII, VIII and II also fell slightly in SHR. Whereas, concentrations of fibrinogen and factor XIII in plasma were slightly higher in SHR than in WKY.
