抄録
The effects of local vibration on blood fibrinolytic activity were studied. (I) The palms of 10 healthy males were exposed to vibration (35Hz, 5G, 5mm p-p) for 5 minutes keeping the normal blood flow in the forearms. The euglobulin fractions were separated from the pre- and post-vibration blood samples. The fibrinolytic activity was measured with the fibrin plate method. It increased after vibration in spite of no hemoconcentration as follows; fibrinolytic areas (pre/post)=4.9±3.9/7.2±5.2mm2. (II) The fibrinolytic activity was kept at high level even 30 minutes after vibration. In case of rabbits with hypercholesterolemia, the activity did not increase. They suggest that the vascular plasminogen activator from the endothelial cells functionally takes part in the increased fibrinolytic activity. (III) In patients with arteriosclerosis (myocardial infarction and cerebrovascular accident, n=36), the fibrinolytic activity (pre/post) were 19.2±8.1/20.4±10.5mm2, though 22.2±18.2/28.2±18.2mm2 in controls (n=30). A possibility of vibration load test is anticipated as a method for the physiological diagnosis of arteriosclerosis.
