種々腎疾患における尿中線溶, 補体系因子の変動

抄録

We have developed highly sensitive enzyme immunoassay or radio-immunoassay of Clq, C3 and FDP in body fluids. For examining relationship between excreted uriniary rare proteins and renal disorders, Clq, C3, IgG, fibrin degradation products (FDP), FDP-E and urokinase (UK) have been measured in daily urine samples from 10 normal volunteers, 23 patients with primary nephritis and 7 patients with secondary nephritis.
Both Clq and C3 excretion were high in the presence of immune complexes in glomeruli. In IgA nephropathy, pericapillary immune deposition rather than mesangial deposition may result in increased in Clq and C3 excretion. In membranous nephropathy, results indicating the activation of alternative pathway of complements were observed. In lupus nephritis, urinary complements excretions were increased at the active phase of the disease. These excretions of complements in urine were not related to the total protein leakage.
Urinary FDP and FDP-E were detected in high levels in cases of impaired renal function. Mesangial proliferation was observed in these patients. In such cases, FDP and FDP-E excretions were not related to the total protein leakage, which suggests that FDP and FDP-E excretions were observed in increase in prolif erative change.
In conclusion, the measurements of urinary rare protein components may be useful for screening of renal disorders.