The fibrinolysis in 6 patients with lupus anticoagulant was studied. The intrinsic fibrinolytic activity by kaolin activated euglobulin with plasminogen free fibrin plate was low level in all patients. Although we could not obtain common results in fibrinolytic factors-plasminogen, α1-AT, α2-M, α2-PI and Cl-inactivator with immunodiffusion method, and in fibrinolytic activity by euglobulin from plasma with ELT and plasminogen rich fibrin plate.
In two patients with Budd-Chiari syndrome, the IgG fraction of plasma through Sephadex G 200 had the inhibitory activity of fibrino (geno) lysis on the fibrin plate method and the immunoelectrophoresis, as well as high lupus anticoagulant activity.
Those findings suggest that fibrinolysis plays a role on formation of thrombus in patient with lupus anticoagulant.
