抄録
Urinary trypsin inhibitor (UTI) had strong anti-plasmin activity with synthetic amido substrate, although little activity was observed with natural fibrin substrate in the assay system. In this paper, anti-fibrinolytic properties of UTI on 11 kinds of non-plasmic enzymes were also compared. Potent inhibitions on chymotrypsin, trypsin, leukocyte protease, earthworm proteases (LR-1 and LR-2), and also a lesser extent on SH-proteases (papain and ficin) were obsereved, whereas the inhibitor showed a trace or no inhibition on LR-3, pronase, pancseas elastase or Bacillus enzyme nattokinase.
The distribution of UTI-related substances in human tissues was first examined with goat UTI-antibody. In contrast to the normal tissues having only limited immunoreactivity (kidney proximal tuble, glia, stomach, colon and bronchial cells), malignant tissues showed widely distributed reactivity, particually in that of the extracellular spaces.
Considering the molecular similarity of UTI to ECGF-2b (Mckeehan et al. 1986) and its broad inhibitry spectrum as proved now, the pathophysiological significances of UTI-related substances were suggested.
