1989 年 20 巻 4 号 p. 346-349
The presence of an inhibitor against factor VIII or factor IX must still be seen as the most important complication in the treatment of hemophilia patients. Brackmann et al. reported successfully induced immune tolerance for hemophilia patients with inhibitor. We tried induction immune tolerance for hemophilia patient with inhibitor.
A hemophilia A patient (10 years old boy) with high level of inhibitor has treated with regular transfusion of low dose factor VIII. Over 30 months factor VIII (about 23u/kg) has transfused 3 times a week. About 6 month later of the beginning treatment the level of inhibitor level has fallen to low level (1.1 Bethesda units) and factor VIII in vivo recovery has improved. The level of inhibitor shows low level over 24 months and bleeding episodes has dramaticaly reduced. The patient is successfully induced immune tolerance and his school life has improved.