It is known that coronary thrombosis is found in 71% of myocardial infarction (massive type), and that the bundle branch block depends on size of thrombosis. There is surely relationship between the myocardial infarction and thrombosis.
Platelet aggregation and the fibrin formation mechanism are of course concerned with the thrombosis, but we are interested specialy in the involvement of the fibrin stabilizing factor. From this respect, we observed the behavior of FSF in myocardial infaction, and reconfirmed from the experiment with dogs that it is specific in the heart. The tests of about 100 normal plasma showed the age dependency, which means the increasing FSF concentration in plasma, is related to age. The mean-SD in adult was 21±3μM MDC/10min. The typical changing pattern of plasma FSF in the myocardial infarction is as follows; it holds at a high level just after the onset, within a short period it then rapidly decreases, next it goes down to the minimum between the 5th-7th day, gradually increases thereafter, and finally returns to a normal level at about the 14th day.
This profile was almost the same as that found in case of experimental dogs, but was not observed in the control surgical operation and brain bleeding or thrombosis in patients. Platelet count and fibrinogen concentration were also checked simultaneously.
The experiment of Master two step test to see the effect on plasma FSF level gave an interesting result illustrated in Fig. 5.
When soluble fibrin monomer appear after the attack while FSF is decreased, there are no noticeable dangerous side effect. The reason of FSF diminution should be investigated; its consumption or correlating inhibition.
