Abstract
Platelet (PLT) products are continuously agitated during storage to ensure preservation of their in vitro and vivo properties. However, PLT products cannot be continuously agitated during shipment. Furthermore, in the case of hospitals with no agitator, a delay in the start of injection of PLT products caused by an emerging change in the condition of a patient may prolong the period of agitation interruption. Here, we studied the effect of a 72-hour interruption of agitation on the in vitro properties of PLTs washed with M-sol.
The washed PLTs, which were stored in a polyolefin bag on an agitator, were divided into two equal aliquots (control and test groups) on Day 1. The test group was removed from the agitator and placed for 72 hours on a laboratory bench. Both groups were sampled on Day 4.
The MPV, %disc, CD62P (%), aggregation, and %HSR values of the test group were not significantly different from those of the control group on Day 4, whereas the pH, pCO2 and lactate values were significantly different.
These results indicate that the effect of a 72-hour interruption of agitation on the in vitro properties of washed PLTs was not particularly marked.
