1982 Volume 28 Issue 1 Pages 1-6
Anti-erythrocyte antibodies were detected in 56 (0.99%) of 5619 patients with various diseases and most of them contained anti-Lewis, Rh and P1 antibodies.
The antibodies were detected in 14 (5.3%) of 264 pregnant women and most of them contained anti-RhD and E antibodies. Moreover, the antibodies were detected in 33 (0.22%) of 14, 900 healthy blood donors, and most of them contained anti-Lewis and P1 antibodies.
The other antibodies seemed to be natural antibodies of type IgM in all healthy blood donors expect three cases, of whom one had a history of blood transfusion and the other two had a history of pregnancy. Most of patients with unidentified antibodies were positive for direct Coombs test but in patients with negative direct Coombs test, the antigen-antibody reaction occurred at low temperature zone by using saline and 22% albumin methods.
These results suggested that such methods as detecting anti-RhD, E Lewis and P1 antibodies should be used in the identification of anti-erythrocyte antibodies.
Moreover, autoimmune hemolytic anemia (AIHA) characterised by positive direct Coombs test developed in a patient with severe epilepsy who had been administered a large amount of anti-epilepsy agents for long term. It was appeared that the cause of AIHA was due to phenitoin (Aleviatin) following clinical course. In case like this patient, all chemicals should be immediately discontinied and other drugs being different structures should be used property, also, hematological and immunological examination should be done.
