ステロイド薬に対する抗体を検出した3症例とその臨床的意義について

抄録

Anti-glucocorticoid (GCS) antibody or antibody-like substances were detected in our three patients with malignant lymphoma, SLE, and SLE combined with AIHA, respectively, by means of the hemagglutination test (HA). The incidence of positive HAs among our patients with collagen diseases was as high as 4.5% (2/44 cases). It was possible to neutralize all antibodies by anti-IgM serum, and the corresponding antigen determinant was supposed to be the common structural portion of the GCSs themselves. Since the results of the HA did not always correspond to those of drug-induced lymphocyte stimulation test (DLST) or the patch test, or to such allergic manifestations as urticaria, a plurality in the mechanisms of antibody production and of allergic manifestations against the GCSs was supposed.