凝集塊のある濃厚血小板の機能について

抄録

Platelet size distribution and aggregation response were studied in platelet concentrates (PCs) containing platelet aggregates. Both normal and abnormal platelet size distribution were observed. As the number of clumps in PC increased, abnormal size distribution patterns also increased. As size distribution became abnormal, aggregability to thrombin decreased. Passage of PC through microaggregate filters did not affect platelet functions.
These in vitro results indicate that some PCs, containing platelet aggregates can be used for transfusions while others can not. The selection of the proper PC can be judged by the number of clumps, and more exactly, by platelet size distribution. PCs of normal size distribution can be used for transfusion provided adequate blood filters are employed.