輸血後非A非B型肝炎における供血者HBc抗体とALT値の意義

抄録

The incidence of transfusion-associated hepatitis was evaluated in 108 patients having surgery who received 547 blood units from healthy donors. Non-A, non-B hepatitis developed in 14 (13.0%) patients. Number of transfusion units was associated with the development of hepatitis. Of 76 patients who received 1-5 units, 8 (10.5%) developed hepatitis, compared with 4 (18.2%) of 22 recipients with 6-10 units and 3 (30.0%) of 10 recipients of 11-19 units.
Patients receiving one unit or more with an elevated ALT level (>20KU/L=41IU/L) had a higher rate of hepatitis than did recipients of blood with a lower level (20.7 vs 13.6%), but the difference was not significant.
Anti-HBc were detected 9.7% of 731 donated blood studied. There was no relationship of donor anti-HBc status to recipient hepatitis.
By the poverty of data on clinial significance of post-transfusion hepatitis and in the economic implications of introduction of anti-HBc screening test, I conclude that such a screening programme cannot be justified in Japan.