親水化ポリエチレン膜を使用したドナープラズマフェレーシス

抄録

A plasmapheresis device with polyethylene membrane filtration (APC-2000, Asahi Medical Co.) was tested for the donor's safety, the efficiency of the device and the quality of collected plasma (protein content, clotting and complement factors). The device is easy to set up and permits to collect 450-480ml of plasma within 35 minutes. As to donor safety, there were no significant changes in the donor's physical and biochemical test results. Complement activation, as already indicated, was noticed to be slightly elevated. Three procedures were stopped becaue of system and disposable circuit failure. The recovery rates of protein's components in obtained plasma were slightly low as compared to those of another membrane device (NDP-100, Nipro Co.). In October 1988 the software system was reformed, which were possible to get good recovery of albumin, IgG, and clotting factors. The increased safety and short collection time will be appealing to volunteer plasmapheresis operations. Since this apparatus is so heavy, it may be recommended to improve it to a portable type for mobile plasmapheresis.