4種類の赤血球保存液の比較試験7施設での検討結果

抄録

Four red cell additive solutions, in which 3 are licenced in the U. S. A. and the last is an experimental additive were evaluated in 7 Blood Centers with the same experimental protocol. The ACD-A-anticoagulated red cells were suspended with one of additives (ADSOL, Baxter; SAGM, Terumo; OPTISOL, Terumo; MAP developed by Dr. S. Sasagawa of Japanese Red Cross) with a hematocrit of 55-65%. Then they were stored in PVC plastic blood bags for 49 days at 4°C. The ATP, 2, 3-DPG levels, morphologic scores, and glucose consumption of red cells were similar in 4 additives. The degree of %hemolysis was the least in MAP. But, the pH levels of RC suspended with MAP were lower by 0.1 unit than those of remaining 3 additives. The resistance to low osmolarity was slightly better in MAP than those of 3 remaining additives. The overall results suggest that MAP and OPTISOL caused a slightly better results in preventing hemolysis, although the data from another parameters indicate that there were no significant differences between 4 additives. Therefore, we should introduce MAP or OPTISOL into the Japanese Blood Program because of the low levels of hemolysis.