抗クロラムフェニコール抗体 (様物質) が検出された膀胱癌の1症例

抄録

Routine antibody detection tests on the serum of a 76-year-old patient with urinary bladder carcinoma disclosed the presence of a cold saline active antibody. The patient's serum, from which anti-I had been previously absorbed, agglutinated all of the panel cells (Ortho) at the room temperature, while the autologous control was negative. The Ortho panel cell suspension products contain chloramphenicol (CP), and further examinations revealed that the panagglutination activity of the patient's serum could be detected only in the presence of CP. Pretreatment of the serum with 2-mercaptoethanol extinguished the activity. These results showed that the activity was attributable to an anti-CP antibody (or antibody-like substance) of IgM. This antibody titers had not varied at all during our 2 months' observation. Administration of CP in the patient's past history could not be verified, while the patient had pyrazolone allergy. In the literature, such anti-CP antibody as seen in this patient has been scarecely reported so far.