血小板輸血不応答患者3例におけるm-PSL大量療法による抗HLA抗体の変動について

抄録

For the purpose of decreasing anti-HLA antibody titer, three patients with the platelet transfusion refractoriness were treated with the bolus of methyl-prednisolone (m-PSL).
In the first and second case, an anti-HLA titer of 128 decreased to 8 after the treatment, but the reactivity and specificity of antibody did not significantly change. In the third case, an anti-HLA titer 4 became negative after the treatment, and the reactivity of antibody deminished with the decreasing of titer, but the specificity did not change. In the addition, when the titer of anti-HLA antibody became negative, corrected platelets increment (CPI) significantly increased by the platelet transfusion from random multiple donors.
m-PSL pulse therapy may be the useful method against the platelet transfusion refractoriness.