Journal of the Japan Society of Blood Transfusion
Online ISSN : 1883-8383
Print ISSN : 0546-1448
ISSN-L : 0546-1448
A NEW TRIAL FOR PERIPHERAL BLOOD STEM CELL COLLECTION: Use of Mobilization by Recombinant Human Granulocyte Colony Stimulating Factor Without Chemotherapy
Manabu HiraiMasahiro TakekawaNobuteru HiraiKazuo TanakaTakao HasuikeKiyo SindoKensuke OtaYoshinori YasuiYoshitaka NakaoHidehiro OhiraTakeshi InoueYoshio FurukawaTakahisa YamaneAtsuko SasakiKeunsik ParkTaesung ImNoriyuki TatsumiTakuya Kishida
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1993 Volume 39 Issue 6 Pages 997-1001

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Abstract
Periheral blood stem cells (PBSC) were collected from six patients by a method using only recombinant human granulocyte colony stimulating factor (rhG-CSF) without the aid of chemotherapy. Four patients with malignant lymphoma and two with acute lymphoblastic leukemia were all in the CR state. rhG-CSF was given subcutaneously for 3 to 5 days when the effect of their last chemotherapies no longer remained (more than 30 days after chemotherapies).
PBSC collection was started 4 or 5 days after initiation of rhG-CSF administration when the leukocyte count reached a mean of 22, 800/μl (range 3, 800-26, 00). The mean number of CFU-GMs was 0.23×105/kg (range 0.023-0.63×105/kg).
This study led us to the conclusion that PBSC can be collected easily and in a shorter time only by mobilization by rhG-CSF.
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© The Japan Society of Transfusion Medicine and Cell Therapy
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