X-RAY IRRADIATION OF RC-MAP PRE-STORED FOR VARIOUS NUMBERS OF DAYS

Effect of X-ray Irradiation on RC-MAP and Reuse of RC-MAP after Irradiation

Abstract

X-ray irradiation is currently in wide use as a means of preventing Post-Transfusion Graft-Versus-Host Diease (PT-GVHD). In this study, we evaluated the effects of X-ray irradiation on RC-MAP pre-stored for various numbers of days, and assessed the length of time irradiated RC-MAP could be resued.
RC-MAP was irradiated at a dosage of 15Gy at 1, 7, 14, 21 or 28 days after blood collection. These specimens were referred to as group I, II, III, IV and V (X-ray-irradiated groups), respectively. Non-irradiated RC-MAP was used as the control.
Results showed that plasma K concentration increased following X-ray irradiation. It is therefore advisable that RC-MAPs be used immediately in infants and in renal failure. However, to maximize the efficiency of blood product use, it seemed possible that groups I and II could be used within two weeks after irradiation, and group III within one week. On the basis of this increase in K concentration, howerver, groups IV and V plasma should be used immediately after irradiation.