採血部位消毒におけるポビドンヨードの有効性について

抄録

We evaluated the efficacy of two skin disinfectants (10% povidone iodine vs. 0.5% chlorhexidine gluconate) at the donor phlebotomy site against three different species of bacteria (Bacillus cereus, coagulase-negative staphylococci, Propionibacterium acnes).
The growth of Bacillus cereus in apheresis-derived platelet concentrates was very rapid with a doubling time of 6 hours, and reached 10⁷CFU/ml within 72 hours. When RC-MAP prepared from whole blood inoculated with Bacillus cereus was stored at 4°C, growth of Bacillus cereus was stopped for 21 days. However, when storage temperature was increased to 22°C on Days 7 or 21, rapid proliferation occurred as was observed in apheresis-derived platelets experiments. Bacterial proliferation was also observed in buffy coat and platelet-poor plasma prepared from whole blood.
No difference was seen between 10% povidone iodine and 0.5% chlorhexidine gluconate in the efficacy of disinfectants against coagulase-negative staphylococci and Propionibacterium acnes. However, disinfection of Bacillus cereus was achieved with 10% povidone iodine only.
Bacillus cereus showed proliferation in all blood components. These results suggest that donor skin disinfectant should be done using 10% povidone iodine in any blood collection.