A CASE OF ANAPHYLAXIS AFTER PLATELET CONCENTRATE TRANSFUSION WITH ANTI-IGA2M (1) AND C9 ANTIBODIES

Abstract

We describe our experience with a 51 year-old Japanese male with hypereosinophilic syndrome and granulocytic sarcoma in whom anaphylaxis had developed several times after transfusions of platelet concentrates. Electric charge of leukocyte-reduction filters or eosionophil counts in the peripheral blood did not show any relationship with anaphylaxis in this patient. Antibodies against IgA2m (1) and C9 were identified by western blotting analysis, but deficiency of IgA2 subclasses or C9 was not detected. These antibodies remain to be studied in regard with transfusion-related anaphylaxis. Because the cause of anaphylaxis following platelet transfusion has not been elucidated in most instances, it should be studied in individual cases to prevent this adverse effect in patients requiring transfusions.