1) We have examined the frequency of Rh-isosensitization in 4000 pregnant women and recognized 8 cases (0.2%) with negative Rh0(D), and 5 cases (0.13%) with positive Rh-antibody.
2) We reported one rare case of Rh-genotype, A, Ccdee among these pregnant women.
3) We investigated 554 pregnant women and their husbands as to the frequency of ABO-isosensitization, and found 46 cases (8.3%) with positive ABO-antibody.
4) We performed replacement transfusion by the Diamond method in 3 case with positive Rh-antibody and one case with positive ABO-antibody. The results were satisfactory.
5) We concluded that erythroblastosis fetalis or icterus neonatorum praecox occurred much more frequently in ABO-incompatibility than in Rh-incompatibility among the Japanese people.