Extrahepatic Biliary Obstruction Associated with Hepatic Large Granular Lymphocytic Lymphoma in a Cat

Abstract

A 9-year-old castrated male domestic cat with sudden onset of extarahepatic biliary obstruction underwent cholecystoduodenostomy. A simultaneous liver biopsy with immunohistochemistry led to a diagnosis of large granular lymphocytic (LGL) lymphoma with hepatocytotropism, which was considered as primary hepatic disease from the subsequent clinical course. Hyperbilirubinemia temporarily improved after surgery but relapsed over the next month. Treatment with L-asparaginase or ACNU resulted in clinical improvement twice, but the cat died of relapse on Day 299 (postoperative day 294). This is the first report of a treated case of feline LGL lymphoma with hepatocytotropism.