An 8-year-old, castrated male, domestic cat presented with acute dyspnea due to a tracheal mass caudal to the larynx. Debulking surgery via a tracheotomy immediately improved her respiratory status, and the cat was discharged on the same day. The resected mass was diagnosed as a diffuse large B-cell lymphoma by histopathology, immunostaining and clonality analysis. Based on cytology, COP therapy (16 times, 5 cycles) was initiated on the day of surgery, followed by doxorubicin treatment (4 times). The cat is still alive without recurrence 958 days postoperatively.
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