Pharmacological Study of Octopin (I)

Actions of Octopin on Motilities of Excised Uterine and Other Autonomic Organs

Abstract

The pharmacological actions of octopin isolated from sepia skin and some oxytocic drugs, i. e. pituitary posterior lobe preparation, adrenaline, acetylcholine, spartein etc. were investigated.1) The guinea pig uterus, nonpregnant and at term, was irresponsive to octopin, while to pituitary posterior lobe preparation responded with strong stimulation. In early pregnancy, the corporol region of guinea pig uterus responded to octopin with the increase of frequency of its contraction, but on the tone as well as the amplitude this drug was less effective.2) Octopin had no effects on the motilities of intestine and the tone of bronchial muscle in guinea pig as well as on the auricular contraction and the tone of ear blood vessels in rabbits.